Archive
Every issue ever sent, and every one of them still on the record. The generator reads this page before it writes tomorrow's — so no paper, no pearl, no pharmacology fact ever gets a second run. It has a very long memory and absolutely no sentimentality about it.
83 issues · nothing repeated · get the next one
October 2026
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No. 083 Mon · Oct 19
Impact of Cannabis Use on Time to Psychiatric Rehospitalization in Young Adults With Bipolar and Psychotic Disorders: A Survival Analysis
AlsoDepressive Symptoms and Health-Related Quality of Life: The Heart and Soul Study
PearlIdentification with the aggressor: the patient may be showing you what was done to them psychodynamic
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No. 082 Sun · Oct 18
Connectomic Determinants of Subcallosal Cingulate Deep Brain Stimulation for Depression
AlsoInterventions to Improve Outpatient Follow-up for Hospitalized Patients With Alcohol Use Disorder: A Systematic Review
PearlHate in the countertransference has to be owned before it stops leaking psychodynamic
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No. 081 Sat · Oct 17
Characterizing Artificial Intelligence Psychosis in a Large Medical Setting
AlsoShedding light on the efficacy of psychodynamic treatment targeting depression for patients with comorbid narcissistic personality disorder
PearlA silence has a transference before it has a meaning psychodynamic
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No. 080 Fri · Oct 16
Psychological Interventions Targeting Auditory Hallucinations in Persons With Psychotic Disorders: A Systematic Review and Meta-Analysis
AlsoDexmedetomidine Use and Intensive Care Unit Admissions for Patients With Medetomidine Withdrawal
PearlOpposite action only works when the emotion doesn't fit the facts dbt
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No. 079 Thu · Oct 15
Incidence of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar-spectrum disorders compared with age-matched and sex-matched individuals in Queensland, Australia: a statewide, hospital cohort study
AlsoClinical Characteristics, Neuroimaging Findings, and Mortality in Korsakoff Syndrome
PearlWorking through: an interpretation that lands once has to be found again psychodynamic
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No. 078 Wed · Oct 14
Attention-Deficit/Hyperactivity Disorder and Late-Life Cognitive Impairment
AlsoMapping negative experiences in psychotherapy: A network analysis
PearlThe doorknob disclosure belongs to the next session, not the next ten minutes psychodynamic
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No. 077 Tue · Oct 13
Pharmacotherapies for Co-Occurring Stimulant Use Disorder and Attention-Deficit/Hyperactivity Disorder: A Network Meta-Analysis
AlsoAntiseizure medication use in pregnancy and the risk of poor fetal growth in the EURAP international registry: a prospective cohort study
PearlWhen a patient asks about your life, explore the question before you answer it psychodynamic
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No. 076 Mon · Oct 12
National Trends in Benzodiazepine Dispensing
AlsoEvaluating Three Treatments for Borderline Personality Disorder: A Multiwave Study
PearlA patient's gift is an association — receive it before you decide what to do with it psychodynamic
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No. 075 Sun · Oct 11
Sex differences in the efficacy, acceptability, and tolerability of antipsychotics in people with acute schizophrenia: individual participant data pairwise, dose-response, and network meta-analyses
AlsoTrust and respect declines and recoveries in psychotherapy: Clinical impact of relational feedback
PearlErotic transference is a message to decode, not a feeling to manage away psychodynamic
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No. 074 Sat · Oct 10
Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness
AlsoHearing Intervention for Older Adults With Mild Cognitive Impairment: The CHOICE Randomized Clinical Trial
PearlIn MBT, move the patient to the pole they're stuck at the opposite end of mbt
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No. 073 Fri · Oct 9
Incidence of clozapine-associated neutropenia in patients with schizophrenia: 20-year population-based study in Hong Kong
AlsoPredicting patient outcomes from initial in-session interactions within cognitive behavioral therapy and person-centered experiential therapy for severe depression
PearlThe late arrival is a message about the frame, not a scheduling problem psychodynamic
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No. 072 Thu · Oct 8
A Digital Therapeutic Intervention for Negative Symptoms of Schizophrenia: A Randomized Clinical Trial
AlsoPrenatal Acetaminophen (Paracetamol) Use and the Risk of Autism and/or Attention-Deficit/Hyperactivity Disorder Among Sibling-Matched Cohorts
PearlIn TFP, the dyad matters less than the moment it flips tfp
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No. 071 Wed · Oct 7
Reducing Ultraprocessed Foods From the Diets of Patients With Depression: A Pilot Crossover Trial
AlsoTransformative pathways: shame and fear of compassion as potential mechanisms of change in psychotherapy
PearlIn supportive therapy, praise has to be accurate to do any work supportive
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No. 070 Tue · Oct 6
Structural brain changes and clinical outcomes of patients with NMDA receptor encephalitis in Germany: a cross-sectional study
AlsoTelehealth Treatment of Anxiety in Patients With Low-Risk Chest Pain in the Emergency Department: The PACER Randomized Clinical Trial
PearlWhen the staff start fighting, the patient's inner world has moved onto the unit psychodynamic
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No. 069 Mon · Oct 5
Changes in Genetic Contributions to ASD and ADHD by Year of Diagnosis
AlsoRandomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder
PearlTermination reopens every earlier separation — set the date early and watch what comes back psychodynamic
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No. 068 Sun · Oct 4
Comparative effectiveness of mood stabiliser monotherapy versus second-generation antipsychotic monotherapy versus combination therapy for continuation and maintenance treatment after a first episode of psychotic mania in North America, Chile, and Spain: a target trial emulation using data from the BD-CAUSAL Collaboration
AlsoToward Personalized Psychotherapy in Anorexia Nervosa: Evidence from Long-Term Moderator Analyses of the ANTOP Study
PearlIn TFP, go to the channel that's carrying the most tfp
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No. 067 Sat · Oct 3
Relapse trajectories and antipsychotic discontinuation in schizophrenia from individual participant data of five trials from the Yale Open Data Access database: a meta-analysis
AlsoOveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials
PearlBoredom in the session is a clinical finding, not a mood psychodynamic
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No. 066 Fri · Oct 2
Comparative efficacy of antipsychotics for reducing aggression in schizophrenia: systematic review and network meta-analysis
AlsoThe efficacy of modified psychodynamic psychotherapy for patients with schizophrenia-spectrum disorders in Germany: a prospective, single-centre, assessor-blinded, parallel-group, randomised controlled trial
PearlPretend mode sounds like insight until you notice nothing moves mbt
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No. 065 Thu · Oct 1
Prior Sexual Violence, PTSD Symptoms, and Recovery Trajectories After New Trauma
AlsoQTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials
PearlTransference work helps most where it looks riskiest psychodynamic
September 2026
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No. 064 Wed · Sep 30
Brain lithium temporospatial kinetics in bipolar disorder: a repeated-measures 7Li MRI study of dosing regimens in Germany
AlsoTreatment dose and reliable change in trauma-focused therapy for comorbid PTSD and MDD
PearlInterpret in displacement before you interpret in the transference psychodynamic
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No. 063 Tue · Sep 29
Association between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure: a retrospective study on two cohorts from Norway and the UK
AlsoExploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study
PearlAnalyze the defense before the content it is hiding psychodynamic
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No. 062 Mon · Sep 28
Structural Brain Correlates of Bulimia Nervosa Diagnosis and Symptom Severity: A Coordinated ENIGMA Eating Disorders Working Group Analysis
AlsoTreatment of Depression in Patients With Alcohol or Other Drug Dependence: A Meta-Analysis
PearlA Role Dispute's Stage — Not Its Content — Tells You Which Technique to Use ipt
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No. 061 Sun · Sep 27
A Phase 2 Randomised, Double-Blind, Placebo-Controlled Trial of Emestedastat in Patients With Major Depressive Disorder and Cognitive Impairment (XanaCIDD Trial)
AlsoCognitive Mechanisms of Change in OCD: Inferential Confusion, Obsessive Beliefs, and Mindfulness Across Three Randomized Treatments
PearlInterpersonal Deficits Treats Isolation as the Illness, Not Its Symptom ipt
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No. 060 Sat · Sep 26
Psychotherapy for Impact of Killing During War: A Randomized Clinical Trial
AlsoNeurological Manifestations in Adult Survivors of Ebola Virus Disease
PearlChain Analysis Finds the Vulnerability, Not Just the Trigger dbt
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No. 059 Fri · Sep 25
Convergence of TMS Sites and Lesion Locations Associated With Nicotine Addiction Improvement on a Common Brain Circuit
AlsoModerating Factors for the Effectiveness of Brief Psychological Intervention for People With Probable Personality Disorder: Secondary Analysis of Data From the SPS Trial
PearlGrandiosity Is Load-Bearing, Not Just Obnoxious psychodynamic
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No. 058 Thu · Sep 24
Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety
AlsoImpact of Cortisol Circadian Rhythm on Psychological Well-Being in Treated Cushing Syndrome: A Cross-Sectional Study
PearlAffect Focus Anchors the Session Before Content Does mbt
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No. 057 Wed · Sep 23
Predicting Long-Term Poor Outcomes in Individuals at Clinical High Risk for Psychosis Using Real-World Clinical Data: The OASIS1000 Prospective Study
AlsoPotential Mechanisms of Change in Virtual Reality-Based CBT and Standard CBT for Schizophrenia-Related Paranoia: A Mediation Analysis From the FaceYourFears Trial
PearlRenegotiating the Contract Is Itself an Intervention, Not an Administrative Reset tfp
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No. 056 Tue · Sep 22
Comparison of Long-Acting Injectable and Oral Antipsychotics in Bipolar Disorder
AlsoTakotsubo Syndrome Diagnosis: The Biomarker-Based BioTAK Score
PearlThe Total Situation Is the Interpretation, Not Just What's Said psychodynamic
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No. 055 Mon · Sep 21
Adolescent Peers' Diagnoses and Genetic Predispositions and Subsequent Risk of Mental Disorders
AlsoBehavioral and Pharmacological Therapies for Late-Life Insomnia: A Randomized Controlled Trial
PearlRole Transition Grief Has to Be Mourned Before It Can Be Solved ipt
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No. 054 Sun · Sep 20
Ketamine Infusions and Rapid Reduction of Suicidal and Depressive Symptoms in Major Depressive Episode: A Systematic Review and Meta-Analysis
AlsoIs More Treatment Truly Better? A Meta-Analysis of the Dose-Response Effect of Individual Psychotherapy for Treatment of Generalized Anxiety Disorder in Adults
PearlContainer-Contained: The Anxiety Has to Land Somewhere Before It Can Be Thought psychodynamic
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No. 053 Sat · Sep 19
Neurometabolites and Antipsychotic Response in Psychosis: A Mega-Analysis
AlsoThe Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID: An Adaptive Randomized Trial
PearlCommunication Analysis Finds the Gap Insight Alone Can't ipt
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No. 052 Fri · Sep 18
The Reinforcement Effect of Social Media Likes in Depression
AlsoA Randomized Controlled Trial Testing the Effects of Sequential Psychotherapy in Depression: Changing Therapist, or Both Therapist and Method?
PearlAn Enactment Is Data, Not a Failure of Technique psychodynamic
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No. 051 Thu · Sep 17
Pharmacological Interventions for Weight Reduction in Patients With Schizophrenia Treated With Antipsychotics: A Systematic Review and Network Meta-Analysis
AlsoSelective Serotonin Reuptake Inhibitors and Bleeding Risk in Patients Undergoing PCI on Dual Antiplatelet Therapy: A Retrospective Cohort Study
PearlTherapeutic Neutrality Was Never the Absence of a Relationship psychodynamic
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No. 050 Wed · Sep 16
Gastrointestinal Interoception and Relapse in Anorexia Nervosa
AlsoCollaborative Working Models of Alliance Rupture Repair: A Theory-Building Case Study
PearlTFP's Clarification-Confrontation-Interpretation Sequence Isn't Optional Order tfp
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No. 049 Tue · Sep 15
Trauma-Focused Therapy Integrated With CBT for Psychosis in People With PTSD and Psychosis: The STAR Trial
AlsoAntipsychotic Exposure and Pharmacologically Treated Type 2 Diabetes in Dutch Youths
PearlThe Negative Therapeutic Reaction: When Getting Better Feels Like a Threat psychodynamic
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No. 048 Mon · Sep 14
GH001 vs Placebo in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial
AlsoDoes Congruence Between Therapist and Patient in Session-by-Session Bond Ratings Predict Change in Symptoms?
PearlSafety Behaviors Don't Just Coexist with the Fear — They Manufacture Its Survival cbt
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No. 047 Sun · Sep 13
Dialectical Behavior Therapy Versus Serotonin Reuptake Inhibitor Treatment for Suicidal Behavior in Borderline Personality Disorder: A Randomized Controlled Trial
AlsoEfficacy and Target Engagement of Dopamine Agonist Pramipexole for Anhedonic Depression: A Randomized Placebo-Controlled Trial
PearlMissing-Links Analysis: Before Assuming "Won't," Rule Out "Can't" dbt
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No. 046 Sat · Sep 12
Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD: A Randomized Clinical Trial
AlsoTherapeutic Alliance and Suicidal Ideation During Therapy and the Role of Racial/Ethnic Identity
PearlAn Interpretation That Explains Everything Leaves the Patient Nothing to Discover psychodynamic
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No. 045 Fri · Sep 11
Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial
AlsoLongitudinal Risk for Suicidal Self-Directed Violence Among Veterans With Cancer
PearlWhen Mentalizing Breaks Down, Rewind the Tape — Don't Push Forward mbt
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No. 044 Thu · Sep 10
Efficacy and Tolerability of Seven Antipsychotic Drugs in Acutely Ill Patients With Schizophrenia: A Randomized, Multicenter, Assessor-Blinded Trial
AlsoSupervised Therapist and Supervisor Impact on Client Therapy Outcomes
PearlFollow the Affectively Dominant Theme, Not the Stated Topic tfp
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No. 043 Wed · Sep 9
Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression: A Randomized Clinical Trial
AlsoBenzodiazepine Prescriptions to Older Adults in the United States, 2015 to 2024
PearlConcordant or Complementary — Your Countertransference Is Telling You Which Character You've Been Cast As psychodynamic
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No. 042 Tue · Sep 8
A Pragmatic SMART Study of Medication and CBT Sequencing in Pediatric Anxiety Disorders: A Randomized Clinical Trial
AlsoGlobal Burden of Disease Attributable to Mental and Substance Use Disorders: Findings from the Global Burden of Disease Study 2010
PearlProjective Identification Is Communication Before It's Defense psychodynamic
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No. 041 Mon · Sep 7
Trends in the Prevalence and Severity of Alcohol and Cannabis Use Disorders Among US Adults
AlsoPersonalized and Optimal Treatment Estimated by a Value-Search Method in a Randomized Clinical Trial With Psychodynamic Versus Cognitive Behavioral Therapy for Depression
PearlIntrojective and Anaclitic Depression Aren't the Same Illness psychodynamic
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No. 040 Sun · Sep 6
Impact of Vagus Nerve Stimulation on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report
AlsoAcute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose
PearlNot All Validation Is the Same Intervention dbt
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No. 039 Sat · Sep 5
Decades After the NIH Revitalization Act: Persistent Gaps in Diversity of US Antidepressant Trials
AlsoTherapist Intrapersonal Factors and Rupture Repair: Professional Self-Doubt, Self-Compassion, and Repair Strategies in a Simulated Cultural Rupture Task
PearlFollow the affect, not the agenda tfp
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No. 038 Fri · Sep 4
Obstetric Risk Associated With Stimulant Versus Nonstimulant Treatment During Pregnancy
AlsoEvaluation of Interventions for Cognitive Symptoms in Long COVID: A Randomized Clinical Trial
PearlNegative capability is a discipline, not a delay psychodynamic
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No. 037 Thu · Sep 3
Open Dialogue versus treatment as usual for adults presenting in crisis to mental health services in England (the ODDESSI Trial): a multisite cluster-randomised trial
AlsoPrediction in routine care: a naturalistic comparison of clinicians and a machine learning model for patients receiving treatment for generalised anxiety disorder
PearlHabituation was never the mechanism — expectancy violation is cbt
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No. 036 Wed · Sep 2
The Typology of Common Psychiatric Disorders as Depicted by Genetic Maps: A Study Based on Swedish Population-Based Registers
AlsoSuicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy
PearlGuided discovery only works if you don't already know the destination cbt
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No. 035 Tue · Sep 1
Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder: An International ENIGMA Bipolar Disorder Working Group Study
AlsoEffectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease (CATIE-AD)
PearlThe selected fact turns noise into a session psychodynamic
August 2026
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No. 034 Mon · Aug 31
Life's Essential 8 Cardiovascular Health and Suicide Mortality: Findings From a Nationally Representative Cohort in South Korea
AlsoObsessive-Compulsive Personality Disorder in Radically Open Dialectical Behavior Therapy for Treatment-Refractory Depression
PearlApparent competence: the DBT skill that fools everyone in the room dbt
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No. 033 Sun · Aug 30
Risk of Presentation for Sexual Abuse After a First Emergency Department Presentation for Self-Harm in Childhood or Adolescence
AlsoThe Effects of Antidepressants on Cardiometabolic and Other Physiological Parameters: A Systematic Review and Network Meta-Analysis
PearlIdentification with the aggressor psychodynamic
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No. 032 Sat · Aug 29
Time Trends in Maternal Attention-Deficit/Hyperactivity Disorder and Medication Use in Pregnancy
AlsoMechanisms of Change in the Treatment of Major Depressive Disorder with Metacognitive Therapy and Behavioral Activation — A Random Intercept Cross-Lagged Panel and Mediation Analyses
PearlReverie isn't empathy -- it's digestion psychodynamic
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No. 031 Fri · Aug 28
Use and Misuse of GLP-1 Receptor Agonists Among People With Eating Disorders
AlsoDepression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways
PearlSymbolic equation: when the metaphor stops being a metaphor psychodynamic
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No. 030 Thu · Aug 27
Integrated mental health treatment and employment services for refugees with PTSD: randomised controlled trial
AlsoIntegrated therapist and online cognitive behavioural therapy in addition to usual care versus usual care for depression in primary care in England (INTERACT): a two-group, parallel, multicentre, randomised controlled trial
PearlOptimal frustration is not empathic failure — it's how structure gets built psychodynamic
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No. 029 Wed · Aug 26
Association of Lithium Use With Suicide and Self-Harm Among Chinese Adolescents and Adults With Bipolar Disorder: A Nationwide Multicenter Retrospective Cohort Study
AlsoAnticholinergic Drug Burden and Incident Cardiovascular Events: A Population-Based Study
PearlSplitting doesn't stay in the room — it recruits the whole team tfp
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No. 028 Tue · Aug 25
Psychological and Psychosocial Interventions for People With Schizophrenia and Co-Occurring Substance Use Disorders: A Systematic Review and Meta-Analysis
AlsoPatients' Perspective on an Optimal Therapeutic Alliance; Facilitating Engagement in Treatment of Antisocial Personality Disorder
PearlThe downward arrow finds the belief the thought record can't touch cbt
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No. 027 Mon · Aug 24
Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial
AlsoA 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD
PearlContract-setting is the intervention before the interpretation tfp
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No. 026 Sun · Aug 23
Pharmacological interventions for ADHD: a systematic review and dose-effect network meta-analysis
AlsoAssessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials
PearlHolding is a technique, not the absence of one psychodynamic
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No. 025 Sat · Aug 22
Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis
AlsoThe Significance of Personality Disorder and Traits in Short-Term Psychodynamic and Cognitive Behavioral Therapy for Major Depression
PearlHypermentalizing is confident, articulate, and wrong mbt
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No. 024 Fri · Aug 21
Nationwide Transdiagnostic Age and Sex Patterns in Mental Disorder Disease Development
AlsoCognitive Rehabilitation and Functional Outcomes in Long COVID–Related Cognitive Impairment: A Randomized Clinical Trial
PearlWithdrawal ruptures and confrontation ruptures need opposite repairs psychodynamic